Table 2 Double-node resistance mechanisms to PI3K inhibitors ordered by their effect on Apoptosis
Perturbation 1 | Perturbation 2 | Apoptosisnorm | Proliferationnorm | Mechanism 1 | Mechanism 2 |
|---|---|---|---|---|---|
MAPK = 2 | MYC = 2 | 0.00 | 0.62 | MAPK | ER |
MAPK = 2 | ER_transcription = 2 | 0.00 | 0.55 | MAPK | ER |
MAPK = 2 | FOXO3 = 1, FOXO3_Ub = 0 | 0.00 | 0.50 | MAPK | AKT |
MAPK = 1 | SGK1 = 1 | 0.00 | 0.25 | MAPK | AKT |
HER2 = 1 | HER3 = 2 | 0.06 | 0.51 | RTK | RTK |
MAPK = 1 | FOXO3 = 0, FOXO3_Ub = 1 | 0.08 | 0.13 | MAPK | AKT |
SGK1 = 1 | ER_transcription = 2 | 0.11 | 0.55 | AKT | ER |
MAPK = 1 | translation = 1 | 0.13 | 0.50 | MAPK | mTORC1 |
MAPK = 1 | TSC = 0 | 0.13 | 0.50 | MAPK | mTORC1 |
MAPK = 1 | PRAS40 = 0 | 0.13 | 0.50 | MAPK | mTORC1 |
MAPK = 1 | mTORC1 = 1 | 0.13 | 0.50 | MAPK | mTORC1 |
SGK1 = 1 | MYC = 2 | 0.25 | 0.63 | AKT | ER |
SGK1 = 1 | FOXO3 = 1 | 0.37 | 0.50 | AKT | AKT |
S6K = 1 | EIF4F = 1 | 0.38 | 0.50 | mTORC1 | mTORC1 |
HER2 = 1 | ER_transcription = 2 | 0.49 | 0.69 | RTK | ER |