Table 1 Single-node resistance mechanisms to PI3K inhibitors ordered by their effect on Apoptosis
Perturbation | Apoptosisnorm | Proliferationnorm | Mechanism |
|---|---|---|---|
PI3K = 1,2; PIP3 = 1,2 | 0.00 | 0.50 | PI3K |
AKT = 1 | 0.00 | 0.50 | AKT |
HER2/HER3 = 2 | 0.00 | 0.50 | RTK |
PIM = 1 | 0.00 | 0.50 | AKT |
MAPK = 1 | 0.25 | 0.25 | MAPK |
MAPK = 2 | 0.00 | 0.25 | MAPK |
BIM = 0 | 0.25 | 0.25 | Apoptosis |
BAD = 0 | 0.25 | 0.25 | Apoptosis |
SGK1 = 1 | 0.25 | 0.25 | AKT |
FOXO3 = 0, FOXO3_Ub = 1 | 0.33 | 0.13 | AKT |
mTORC1 = 1 | 0.38 | 0.50 | mTORC1 |
translation = 1 | 0.38 | 0.50 | mTORC1 |
TSC = 0 | 0.38 | 0.50 | mTORC1 |
PRAS40 = 0 | 0.38 | 0.50 | mTORC1 |
MCL1 = 1 | 0.38 | 0.25 | Apoptosis |
BCL2 = 1 | 0.50 | 0.25 | Apoptosis |
pRb = 3 | 0.70 | 0.50 | Proliferation |
E2F = 3 | 0.70 | 0.50 | Proliferation |
cycE_CDK2 = 1 | 0.70 | 0.50 | Proliferation |
p21_p27 = 0 | 0.70 | 0.49 | Proliferation |