Fig. 4
Network model response to PI3K inhibitors. a Time course of node activity (based on 10,000 simulations) in response to PI3K inhibition from time = 2. Only the nodes that change during the time course are shown. For multi-state nodes, we show the node activity for each node state and denote each state of a multi-state node with a “_n”, where n is the state it is referring to (e.g. MAPK_1 refers to state 1 of MAPK and MYC_2 refers to state 2 of MYC). The Apoptosisnorm and Proliferationnorm is a weighted and normalized (between 0 and 1) measure of the state of the node Apoptosis and Proliferation, respectively. b-c Time course of selected nodes, each representative of a different pathway. Panel C zooms in to the early time points of Panel B