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Fig. 3 | Cancer Convergence

Fig. 3

From: A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer

Fig. 3

Network model of oncogenic signal transduction in ER+ breast cancer. The nodes are colored according to the pathway they are part of: RTK signaling, PI3K signaling, MAPK pathway, AKT pathway, mTORC1 pathway, ER signaling, cell-death signaling (apoptosis) and cell-cycle regulation (proliferation). The network also includes selected drugs of interest in the context of breast cancer: Alpelisib (PI3K inhibitor), Ipatasertib (AKT inhibitor), Fulvestrant (ER inhibitor), Palbociclib (CDK4/6 inhibitor), Everolimus (mTOR inhibitor), Trametinib (MEK inhibitor), and Neratinib (HER1/2 inhibitor). For clarity of the figure, we merge certain nodes into a single node when there is no ambiguity; for example, a node denoting a transcript is merged with the protein it codes, e.g., BCL2 and BCL2_T (for BCL2 transcript) are shown as BCL2. The full list of network nodes is indicated in Additional File 1

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Cancer Convergence

ISSN: 2366-6196

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