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Fig. 6 | Cancer Convergence

Fig. 6

From: Distinguishing mechanisms underlying EMT tristability

Fig. 6

Overexpression of SNAIL is not sufficient to initiate EMT in absence of ZEB1 and FOXC2. (a) Integrating FOXC2 to the TCS framework – TCS-FOXC2. (b) Top panel: Bifurcation diagram of the TCS-FOXC2 circuit when FOXC2 is present, as reflected by S I  = 0. Bottom panel: Bifurcation diagram of the TCS-FOXC2 circuit when FOXC2 is absent, as reflected by S I  = 2105 molecules. (c) Western blot analysis of EMT markers upon SNAIL overexpression in HMLE cells, and FOXC2 suppression in HMLE–Snail cells respectively. (d) The proposed EMT regulatory framework integrating transcriptional regulation by FOXC2

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