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Fig. 3 | Cancer Convergence

Fig. 3

From: Distinguishing mechanisms underlying EMT tristability

Fig. 3

Simulation of the responses of SNAIL and ZEB1 to EMT-inducing signal S A by the TCS model on single-cell (a) and population levels (b). For each figure, six different levels of S A are chosen - S A  = 0,  20,  36,   49,   64,   90 (103 molecules). The distributions of mRNA and protein levels of SNAIL and ZEB in response to different levels of S A are calculated by Langevin simulation. For (b) and (c), white noise to mimic the fluctuations inside one cell is considered. For (e) and (f), parameter randomization to mimic the cell-cell variability is included. The trimodal distribution of ZEB1 mRNA levels when S A  = 49103 molecules during EMT is highlighted in both (c) and (f)

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