Fig. 6
From: Probing three-dimensional collective cancer invasion with DIGME
A ring diskoid in circularly aligned collagen matrix simulating a ductal carcinoma. a schematics showing the invasion of a typical ductal carcinoma. b A confocal slice showing the MDA-MB-231 ring diskoid (red) surrounded by circularly polarized collagen fibers (green). c Top views of the sample at day 0, 5, and 10. d Invasion distance d f as a function of time. e Histogram of cell orientation θ at 10 days. θ is the angle between the cell long axis and the local radial direction measured from the seeding center of the diskoid C v